Vietnamese Journal of Neurology

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Articles Issue: Vietnamese Journal of Neurology No.44 Nghiên cứu

Direct oral  anticoagulants versus warfarin in the treatment of cerebral venous thrombosis in bach mai hospital

Published: March 17, 2025
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Abstract

Cerebral venous thrombosis (CVT) is a rare type of stroke that carries a risk of recurrence, including conditions such as limb venous thrombosis and pulmonary thrombosis… A cross-sectional study conducted at Bach Mai Hospital from January 2022 to June 2024 evaluated the safety and efficacy of oral anticoagulants, including direct oral anticoagulants (DOAC) and warfarin, in 47 patients diagnosed with cerebral venous thrombosis. The study found that the average age of the participants was 44.7 ± 16.8 years. The complete recanalization rates for the groups using DOAC and warfarin were 80.5% and 66.7%, respectively. Additionally, the proportion of patients achieving a favorable recovery, indicated by an mRS score of 0-1, was 80.5% for the DOAC group and 83.3% for the warfarin group. Importantly, the rates of recurrent venous thrombosis and bleeding events were low, at 2.4% and 4.9%, respectively. This study provides valuable information regarding the efficacy and safety of both DOAC and warfarin for patients with CVT, aiding clinicians in making informed decisions about anticoagulant therapy.

References

1.
Saposnik G, Bushnell C, Coutinho JM, et al. Diagnosis and Management of Cerebral Venous Thrombosis: A Scientific Statement From the American Heart Association. Stroke. 2024;55(3):e77-e90. doi:10.1161/STR.0000000000000456
2.
Saposnik G, Barinagarrementeria F, Brown RD, et al. Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42(4):1158-1192. doi:10.1161/STR.0b013e31820a8364
3.
Ferro JM, Canhão P, Stam J, et al. Prognosis of Cerebral Vein and Dural Sinus Thrombosis: Results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke. 2004;35(3):664-670. doi:10.1161/01.STR.0000117571.76197.26
4.
Einhäupl K, Stam J, Bousser MG, et al. EFNS guideline on the treatment of cerebral venous and sinus thrombosis in adult patients. Eur J Neurol. 2010;17(10):1229-1235. doi:10.1111/j.1468-1331.2010.03011.x
5.
Ferro JM, Bousser MG, Canhão P, et al. European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis - endorsed by the European Academy of Neurology. Eur J Neurol. 2017;24(10):1203-1213. doi:10.1111/ene.13381
6.
Ferro JM, Coutinho JM, Dentali F, et al. Safety and Efficacy of Dabigatran Etexilate vs Dose-Adjusted Warfarin in Patients With Cerebral Venous Thrombosis: A Randomized Clinical Trial. JAMA Neurol. 2019;76(12):1457-1465. doi:10.1001/jamaneurol.2019.2764
7.
Yaghi S, Shu L, Bakradze E, et al. Direct Oral Anticoagulants Versus Warfarin in the Treatment of Cerebral Venous Thrombosis (ACTION-CVT): A Multicenter International Study. Stroke. 2022;53(3):728-738. doi:10.1161/STROKEAHA.121.037541
8.
Khaladkar SM, Thakkar DK, Thakkar DK, et al. Cerebral venous sinus thrombosis on MRI: A case series analysis. Medical Journal of Dr DY Patil University. 2014;7(3):296. doi:10.4103/0975-2870.128964
9.
Duman T, Uluduz D, Midi I, et al. A Multicenter Study of 1144 Patients with Cerebral Venous Thrombosis: The VENOST Study. Journal of Stroke and Cerebrovascular Diseases. 2017;26(8):1848-1857. doi:10.1016/j.jstrokecerebrovasdis.2017.04.020
10.
Maqsood M, Imran Hasan Khan M, Yameen M, et al. Use of oral rivaroxaban in cerebral venous thrombosis. J Drug Assess. 2020;10(1):1-6. doi:10.1080/21556660.2020.1838769
11.
Yy J, Lj C, Xj W, et al. Efficacy and Safety Assessment of Rivaroxaban for the Treatment of Cerebral Venous Sinus Thrombosis in a Chinese Population. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. 2022;28. doi:10.1177/10760296221144038

Authors

Vo Hong Khoi Vu Hong Thai

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